Category Archives: Positions available

PDRA in micro-Raman and fluorescence of soil microbiology

A 18-months (12-months and possible 6-months extension) postdoctoral fellow in the field of spectroscopy and fluorescence microscopy is available in the LIEC-Aiguillettes Laboratory at Vandoeuvre-les-Nancy, France (http://liec.univ-lorraine.fr), under the supervision of Dr. Aurélie Cébron.

The successful candidate will conduct ANR-funded research (Rhizorg project) on the analysis/visualization of bacterial pure cultures and soil samples using fluorescence microscopy (bacterial cell-labelling using Fluorescence in situ hybridization: FISH technique) combined with FT-Raman spectroscopy. Raman microspectroscopy has the potential to monitor and identify polycyclic aromatic hydrocarbon (PAH) and/or PAH-degrading bacteria using 13C-labelled Phenanthrene. Cell labelling (FISH) and analysis of Raman spectral profiles will constitute the core research of the PostDoctoral position.

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PhD – University of Reims Champagne Ardenne

We are planning to apply for half-funding for a doctoral contract with our university (University of Reims Champagne Ardenne). We are looking for an opportunity to supplement financing from a partner interested in a joint PhD. The topic of the project would concern processing of vibrational data collected on tissue sections (unsupervised feature selection and clustering, multi-objective optimization for spectral histology).

For additional details, please contact Cyril Gobinet (cyril.gobinet@univ-reims.fr) and Olivier Piot (olivier.piot@univ-reims.fr).

PDRA (Brazil) – Nanoparticles, in vivo Cancer Diagnosis and Raman

Post doc position on Nanoparticles and in vivo Cancer Diagnosis by Raman Spectroscopy

Two postdoctoral positions in cancer diagnosis by in vivo Raman Spectroscopy are available at the Laboratory of Biomedical Vibrational Spectroscopy (LEVB), UNIVAP, São José dos Campos – BRAZIL. The successful candidate will also take responsibility for the collaborative research between LEVB and National University of Singapore (Singapore) for the development of the project “Nano Biophotonics applied for biological systems” Computational and spectroscopic analysis of cosmetic permeation through human skin” supported by CNPq – International Cooperation program.

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PDRA (Diamond) – IR microscopy via FPA on MIRIAM beamline

Post Doctoral Research Associate on full field IR microscopy via Focal Plane Array (FPA) detector at MIRIAM beamline B22 of Diamond.

Further information is available at:
http://www.diamond.ac.uk/Careers/Vacancies/All/DIA0993_CH.html

Deadline: 22 March 2015
Duration: 3 years

The PDRA will first implement a new optics scheme designed to further exploit the SR brightness advantage via the use of high magnification objectives. He/she is then expected to perform in-house/collaborative research within the widest fields of IR applications, from biomedicine to life sciences in general.

For more details please contact gianfelice.cinque@diamond.ac.uk

Lab webpage: http://www.diamond.ac.uk/Home/Beamlines/B22.html

 

PDRA Univ. Reims – spectral data processing and clinical data management

Post-doctoral position in development of vibrational microscopy for cancer cell characterization: spectral data processing and clinical data management

A post-doctoral position is available in the frame of a European project (Competitiveness and Innovation framework Programme) entitled M3S for Molecular Signature Detection with Multi-modal Microscopy Scanner. The project is led by a multidisciplinary consortium comprising academia, clinical, and industrial partners.

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PhD at Strathclyde

Creating an Automated Analysis Toolbox for Ultrafast 2D-IR Spectroscopy

Applications are invited for a cross-disciplinary PhD project that aims to develop new data analysis methods for use with ultrafast 2D-IR spectroscopy.

2D-IR uses ultrafast infrared lasers to obtain important new information on the structure, dynamics and interactions of molecules in solution. It is particularly powerful when applied to observing chemical or biological reactions in real time.

The project is a collaboration between the groups of Dr Neil Hunt (Physics, Strathclyde), Prof Tony Parker (STFC Rutherford Appleton laboratory) and Dr Matt Baker (Chemistry, Strathclyde) and will suit candidates with a background in physical chemistry or chemical physics or a related area.

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PhD studentship at Lancaster (2)

Raman microspectroscopic analysis of live cells during abiotic perturbations

Department of Chemistry, Lancaster University

Primary Supervisor: Dr Lorna Ashton

Live cell imaging is an important analytical tool for many areas of biomedical research including cell biology, neurobiology, pharmacology and developmental biology. With the continuing development of Raman microscopy this analytical technique now offers an alternative, label-free imaging approach capable of providing vast amounts of spatially resolved biochemical information.

The aim of this project will be to develop live cell Raman imaging using a Raman microscope coupled to a cell incubator in which cells can be grown and maintained in normal culturing conditions by regulating humidity, carbon dioxide levels and temperature. Once optimum conditions have been established the cell environment will be perturbed in a variety of ways including, the addition of specific chemicals and drugs to the medium, carbon dioxide levels, temperature and potentially mechanical forces, in order to monitor the biochemical response of the cells. As well as carrying out cell culture and Raman spectroscopy, the project will involve the development of data analysis techniques for the interpretation of spatially resolved biochemical information. This project is suitable for those with a background in chemistry, biochemistry or biology.

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PhD studentship at Lancaster (1)

Cannabinoid mode of action in gut epithelial organoids using live cell Raman microscopy

Biomedical and Life Sciences, Lancaster University

Primary supervisor: Dr Karen Wright
Co-supervisor: Dr Lorna Ashton

This project will combine advanced cell culture modelling with Raman technology to monitor the distribution and localisation of plant-derived, endogenous and synthetic cannabinoids in real time in both 2D and 3D gut epithelial cultures under both normal and inflammatory conditions. By investigating the nucleic acid, phenylalanine and lipid regions, their effects on cells will be monitored. Mapping the transfer of cannabinoids to regions of the cell and the specific organelle will provide proof of principle for this technology to advance the field of drug development. In addition, the identification and characterization of cellular architecture within the 3-dimensional intestinal organoid will potentially provide new ways to distinguish between healthy and infected or cancerous cells.

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PhD Position – Living cells nanocalorimetry and Synchrotron FTIR imaging

BBSRC funded PhD student open position – Royal Holloway University of London and Diamond Light Source

Living Cells Nanocalorimetry and Synchrotron FTIR imaging

Please visit http://www.findaphd.com/search/ProjectDetails.aspx?PJID=60475

The aim of this research project is to combine thermodynamic analysis of micro- and nano-sized biological objects, e.g. individual cells, cell compartments or individual organelles and, ultimately individual molecules with analytical method such as Synchrotron Radiation InfraRed microprobe.

This project is a collaboration between Royal Holloway University of London (Supervisor Mikhail Soloviev) and the Diamond Light Source, Harwell Science & Innovation Campus (Co-supervisor Gianfelice Cinque).

Deadline 31st January 2015

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